Micky van de Ven Double Halts The Toffees' Unbeaten Streak at New Stadium
The Dutch defender became the initial backline player to score twice in a Premier League game for Spurs since the Belgian defender in spring 2013.
At a glance
The Spurs defender heads home twice in opening period
Everton's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr scores final goal in dying moments
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and handed the Toffees their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after 133 years at the end of last season.
But Spurs captain Van de Ven pounced twice from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were unable to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - headed home a final goal to put the game to bed.
The Everton defender thought he had equalized the scores a short while after Van de Ven's opener, glancing a bullet header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a succession of excellent stops to guarantee the London club went five matches on the road without defeat in the Premier League.
But the VAR intervened, instructing the match official to review the score on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
This victory elevates the manager's team into third place in the division, five points off local foes and table-toppers the Gunners.
Everton remain 14th and sit half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven fulfils role at each end of pitch
After a drab midweek display in the Champions League against the French side, where they managed a only attempts on goal, the manager chose the French striker in attack instead of former Toffees player the Brazilian.
The new arrival was failed to make much of an impact before being replaced for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the end.
Centre-back Van de Ven transformed into an attacking force to be feared.
Tottenham's opening strike came from a well-worked corner routine, with the midfielder heading the ball back across the six-yard box for an free the defender to head home.
And the captain - stepping up as skipper in the Argentine's absence - notched his second in added time as he outjumped Jordan Pickford to nod in.
The Dutchman was equally impressive in defensive duties, partnering effectively with Kevin Danso as the duo dealt excellently with the 34 crosses thrown their way by the opposition.
Everton analysis: Everton missing striker's instinct
Everton's new home had been a fortress, but it seems the freshness may have faded slightly and fans headed to the gates after Sarr's final goal for Spurs.
The end in the team's unbeaten home run won't be a massive worry for the manager, but their striker situation are.
The forward and Thierno Barry - the Everton's pair of recognised centre-forwards - had netted only one league goal combined before the weekend's match.
And they were unable to add to that poor tally on a damp and dreary night on in Liverpool.
Beto's performance was epitomized when he chose to overhead kick a clear chance from near the goal, even with having space and opportunity to reposition for a simpler attempt that would have tested Vicario.
Barry, too, failed to make an impact after coming on for Beto in the 65th minute.
It was not for a lack of chance. The majority of the home side's offensive moves came through Grealish and the forward, who tirelessly delivered threatening balls into the Spurs penalty area.
What next for these two sides?
The Toffees: Moyes' men travel to Sunderland in the top flight on Monday, 3 November at 8 PM.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against Newcastle.